The research article “Structural and Biological Analysis of Mesoporous Lanthanum Doped βTCP For Potential Use as Bone Graft Material”, co-authored by METU members Res. Asst. Ali Deniz Dalgıç, Prof. Dilek Şendil Keskin and Prof. Zafer Evis has been published in Materials Today Communications.
In this study, mesoporous particles of β-tricalcium phosphate (βTCP, βCa3(PO4)2) and lanthanum (La) doped βTCP were synthesized using wet precipitation method attached with microwave refluxing system. The obtained materials were characterized and analysed using different sort of techniques such; X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), Inductively coupled plasma optical emission spectroscopy (ICP-OES), Brunauer–Emmett–Teller (BET) and helium pycnometer. With incorporation of La3+ ions, relevant expansion in lattice parameters of βTCP crystal was observed along with inhibition growth rate was observed. βTCP and La- βTCP materials were mesoporous in nature, pore diameter and pore volume were expanded with incorporation of La3+ ions. The loading /release on βTCP and La- βTCP particles surfaces were evaluated using fetal bovine serum (FBS) proteins. In vitro cell culture studies were performed with human osteosarcoma cell line (Saos-2). The outcomes approved that all La-βTCP materials were cytocompatible and strict dose dependent effect of La3+ ions was observed on cell viability and alkaline phosphatase (ALP) activity. These results strongly suggest that La-βTCP materials have a potential application in bone tissue engineering.
Motameni, A., Dalgic, A. D., Alshemary, A. Z., Keskin, D., & Evis, Z. (2020). Structural and biological analysis of mesoporous lanthanum doped βTCP for potential use as bone graft material. Materials Today Communications, 23 doi:10.1016/j.mtcomm.2020.101151
Article access: https://www.sciencedirect.com/science/article/pii/S2352492820311284
Res. Asst. Ali Deniz Dalgıç |
Web of Science/Publons Researcher ID: K-3623-2017 |
| alideniz@metu.edu.tr | Scopus Author ID: 57193756153 |
| About the author | ORCID: 0000-0003-2529-3340 |
Prof. Dilek Şendil Keskin |
|
| dkeskin@metu.edu.tr | Scopus Author ID: 36967297400 |
| About the author |
Prof. Zafer Evis |
|
| evis@metu.edu.tr | Scopus Author ID: 14070067300 |
| About the author | ORCID: 0000-0002-7518-8162 |
Tags/Keywords:
Bone graft materials, In vitro degradation, Lanthanum, Mesoporous particles, β-Tricalcium phosphate
Other authors:
Motameni, A. (METU) & Alshemary, A. Z.
