Synthesis and characterization of magnesium-lanthanum dual doped bioactive glasses

The research article “Synthesis and characterization of magnesium-lanthanum dual doped bioactive glasses”, co-authored by METU members Prof. Zafer Evis, Prof. Dilek Keskin and Prof. Ayşen Tezcaner, has been published in Ceramics International.

Dual ion-doped bioactive glass has drawn high attention during recent years because of well-improved therapeutic characteristics and mechanical properties. In this study, 5 different ion-doped (1 wt% Lanthanum with 0, 1, 2.5, 5, and 10 wt% Magnesium) 58S bioactive glasses (BGs) were synthesized. The physicochemical results revealed that Lanthanum (La) and Magnesium (Mg) ion doping has been successfully done. Mechanical characterization results depicted that La-doped and Mg-La double doped samples with Mg less than 2.5 wt% had higher diametral tensile strength compared to BG and other co-doped samples. However, Vickers hardness values were not affected by ion dopings. Apatite formation and bioactivity were also improved in double ion-doped samples, especially in those with the higher magnesium content. Cell culture studies showed that synthesized BGs were not cytotoxic. Especially, groups having 2.5 to 5 wt% Mg showed the highest cell viabilities at day 7. Results indicated that Mg- La dual doped bioactive glasses possess improved properties compared to BG, and thus, have potential for bone regeneration applications.

Jodati, H., Güner, B., Evis, Z., Keskin, D., & Tezcaner, A. (2020). Synthesis and characterization of magnesium-lanthanum dual doped bioactive glasses. Ceramics International, 46(8), 10503-10511. doi:10.1016/j.ceramint.2020.01.050

Article access: https://www.sciencedirect.com/science/article/pii/S0272884220300511

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Other authors:
Jodati, H. (METU) & Güner, B. (METU)